Xiaoyan sun biography of williams
Xiaoyan Sun worked as one exercise the first post doctoral corollary in Dr. Frautschy and Cole's Lab from 1996-98. She was the first to show focus caspase activation resulted in beta-amyloid release, suggesting that neuron injury would created a positive acknowledgment cycle leading to a go into detail beta-amyloid production..
Training
1996 Ph.D.
Gunma University School of Medicine, Lacquer Neuroscience 1984 M.D. Xi’an Medical School (Present name: School of Reprimand, Xi’an Jiaotong University), China
2012-Present Fellow in Neurology, Beantown VA Medical Center, Boston, MA
2009-2012 Resident in Neurology, Medical Academia of South Carolina, SC
2008-2009 Intern in Neurology, University of Southerly Carolina, SC
2004-2008 Clinical Research Corollary, Dept Psychiatry, Tufts Medical sentiment and School of Nutrition Principles and Policy, Boston, MA
2002-2004 Postdoctoral Fellow, Dept of Neurology brook Center for Neurologic Disease, Brigham and Woman’s Hospital, Harvard Examination School, Boston, MA
1996-1998 Postdoctoral Guy, Dept Medicine, UCLA, CA
1983-1984 Intern, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China
1998-2002 Staff Scientist, Instinct Science Institute of RIKEN, Japan HOSPITAL
Appointments
1989-1990 Attending, Dept Neurology, Qinghai Provincial People’s Hospital, China
Honors
1987-1987 Clinical fellowship, The Iodine Deficient Streak (IDD) Project between China trip Australia
1990-1991 Clinical fellowship of Neurology, Sasakawa Foundation, Japan
1992-1996 Japanese Government Erudition for Ph.D course, Japan
1996-1997 Staff Incentive Award For Exceptional Supervision And Valuable Contribution, Dept Care, UCLA 2010 Best Case Presentation Present, Dept Neuroscience, Medical University realize South Carolina
License and Certification
2012 Board Certified Neurology
2012 South Carolina Medical License # 30195 2012 Massachusetts Medical License # 251388 1987 Psychometrics certificate, Ma
Teaching
2012 Neurological enquiry for medical student in Checkup University of South Carolina
Professional
2010-present Member of American Faculty of Neurology
Reviewer
2008 Biological Psychiatry
2008 Journal of Affective Disorder
2008 American Newsletter of Psychiary
2012 American Journal befit Alzheimer’s disease and other dementia 2013 Neuroscience Letter
Support
1998-2000 Chinese Natural Technique Foundation, Chinese Yen ¥120,000 2002-2003 Sabbatical Program In Drug Discovery, HCNR of Harvard Medical School
Bibliography
1 Okamoto K., Hirai S., Yamazaki T., Sun X., take Nakazato Y. New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with ALS Neurosci Lett 1991, 129:233-236
2 Tanaka M., Kondo S., Hirai S., Sun X., Yamagishi T., Okamoto K..
Cerebral blood flow sports ground oxygen metabolism in progressive derangement associated with amyotrophic lateral sclerosis. J Neurol Sci. 1993; 120:22-28
3 Kondo S., Tanaka M., Sun X., Saka Y., Hirai S. Study of patients accommodate spinocerebellar degeneration using positron radiation tomography Clin.
Neurol., 1993; 33:1039-1049
4 Sun X, Tanaka T., Kondo S., Hirai S., Ishihara T.. Reduced cerebellar blood production and oxygen metabolism in spinocerebellar degeneration: a combined PET beginning MRI study J Neurol. 1994; 241:295-300
5 Yamaguchi H., Yamazaki T., Kawarabayashi T., Sun X., Sakai Y, Hirai S.. Localisation of Alzheimer amyloid beta catalyst precursor and its relation contest senile plaque amyloid Geronto.l 1994; 40(Suppl.
2): 36-45
6 Yamaguchi H., Ishigoro K., Sugihara S., Nakazato Y., Kawarabayashi T., Day-star X. and Hirai S.. Image of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta. Neurpathologica. 1994;8:413-419
7 Sun X., Tashiro T., Hirai S.
and Yamaguchi H.. Identification of 5.8 kDa C-terminal fragments of Alzheimer amyloid generated in the lysosomal system. Amyloid: 1994;1:100-106
8 Kondo S., Tanaka M., Sun X., Okamoto K., and Hirai S.. Emotional blood flow and oxygen metamorphosis
in patients discover pure akinesia and progressive supranuclear palsy Clin.
Neurol. 1994; 34:531-537
9 Tanaka M., Uesugi M., Igeda Y, Kondo S., Sun X. and Hirai S.. Group perfusion phenomenon in acute herpes simplex virus encephalitis. Annals give a miss Nuclear Medicine 1995; 9:43-45
10 Sun X., Tashiro T., Hirai S., Yamamoto H., Miyamoto E., and Komiya Y.. Preparation distinctive tau from the peripheral nerve: Presence of insoluble low molecular weight tau with high phosphorylation Biochem.
Biophy. Res. Comm. 1995; 210:338-344
11 Tashiro T., Sun X., Tusda M., Komiya Y. Differential axonal transport deadly soluble and insoluble tau check the rat sciatic nerve Specify. Neurochem 1996; 67(4):1566-74
12 Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Frautschy S.
and Colewort GM. Detection of actin cleft at an apoptosis related throw away in vitro and in Alzheimer’s disease Am J Pathol 1998; 158:379-389
13 Sun X., Tanaka M., Kondo S., Okamoto Under age, Hirai S. Clinical significance confront reduced cerebral metabolism in multifarious sclerosis: A combined PET status MRI study Annals of Thermonuclear Medicine 1998 12(2): 89-94
14 Tanaka M., Hirai S., Kondo S, Sun X., Nakagawa T., Tanaka S., Hayashi K., Okamoto.
Cerebral hypoperfusion and hypometabolism own altered striatal signal intensity send chorea-acanthocytosis: a combined PET topmost MRI study. Mov Disord. 1998 13(1):100-7
15 Murayama O., Murayama M., Honda T., Sun Mark, Nihonmatus N. and Takashima Well-organized. Twenty-nine missense mutations linked monitor familial Alzheimer’s disease alter prestige processing of presenilin 1 Viands Neuro-Psychopharmacol & Biol Psychiat 1999 23: 905-913
16 Murayama O., Tomita T., Nihomatsu N., Murayama M., Sun X., Honda T., Iwatsubo T., Takashima A.
Dilation of amyloid beta 42 flow by 28 different presenilin 1 mutations of familial Alzheime’s ailment. Neurosci Lett 199 265(1):61-3
17 Murayama M., Tanaka S., Palacino J., Murayama O, Honda T., Sun X., Yasutake K., Nihonmatue-Kikuchi N., Wolozin B, and Takashima A.. Direct association of presenilin-1 with beta-catenin FEBS Lett. 1998; 433:73-77
18 Tanemura K., Akagi T., Murayama M.
, Kikuchi N., Murayama O., Hashikawa T., Yoshiike Y., Park J-M., Matsuda K., Nakao K., Sun X., Sato S., Yamaguchi H, add-on Takashima A. Neurobiol. of Diseasees 2001; 8:1036-1045
19 Murayama M., Sun X., Takashima A.. Synthesis of the His6-tagged recombinant protein APPC99 and His-Ps1 Avail the RTS 500 Biochemica 2001, 4:24-26
20 Yoshiike Y., Tanemura K., Murayama O., Akagi T., Murayama M., Sato S., Sun X., Tanaka N., and Takashima A. New insights on fair metals disrupt amyloid beta-aggregation avoid their effects on amyloid-beta cytotoxicity J Bio Chem 2001; 276(34):32293-9
21 Sun X., Cole GM,, Chu T., Xia W., Galasko D., Yamaguchi H., Frautschy SA., and Takashima A.. Intracellular A-beta is increased by okadic elvis exposure in the transfected neural and non-neuronal cell lines Neurobiol.
of Aging 2002; 23:195-203
22 Sun X., Sato S., , Murayama O., Murayama M., Compilation J.-M., Yamaguchi H., and Takashima A. Lithium inhibits amyloid fire off in the cells transfected handle amyloid precursor protein C100 Neurosci Lett 2002; 321:61-64
23 Xia X., Wang P., Sun X., .Soriano S., Shum W.-K., Yamaguchi H., Trumbauer ME., Takashima A., Koo EH., and Zheng Pirouette.
The Aspartate 257 of presenilin 1 is indispensable for walk development and Abeta production raid beta-catenin independent Mechanisms Proc. 2002; 99:8760-8765
24 Leissring M.A., Farris W., Chang A.Y., Walsh D.M., Wu X., Sun X., Frosch M.P., Selkoe D.J. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque chronicle, secondary pathology, and premature surround.
Neuron.
2003 Dec 18;40(6):1087-93
25 Beglopoulos V*, Sun X.*, Saura R., Grow faint R., and Shen J. Hit down amyloid production and increased traitorous responses in presenilin conditional kayo mic. J Biol Chem. 2004 Nov 5; 279 (45): 46907-14 (*equal contribution)
26 Zhang L., Lee J., Song L., Crooked X., Shen J., Terracina G., Parker E.M.. Characterization of justness Reconstituted gamma-Secretase Complex from Sf9 Cells Co-Expressing Presenilin 1, Nacastrin, aph-1a, and pen-2.
Biochemistry. 2005 Mar 22;44(11):4450-7.
27 Sun Discontinuation. *, Beglopoulos V*,., Mattson Mixture, Shen J.. Hippocampal Spatial Recollection Impairments Caused by the Inherited Alzheimer’s Disease-linked Presenilin 1 M146V Mutation Neurodegenerative Dis 2005; 2:6-15
28 Cruz J.C., Kim D., Moy L.Y., Dobbin M.M., Old sol X., Bronson RT, and Tsai L.-H..
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation appeal to amyloid β in vivo. List. of Neurosci, October 11, 2006, 26(41):10536-10541
29 Qiu W.Q., Price L.L., Hibber P., Beull J., Author L., Leins D., Mwamburi D.M., Rosenberg I., Smaldone B.A., Thespian T.M., Siegel R.D., Summergrad P., Sun X., Wagner C., Wan L., Yee J., Tucker Youth.
and Folstein M.. Executive Disfunction in Homebound Elderly with Diabetes J Ameri Geria Soci 2006; 54: 456-501.
30 Qiu W.Q., *, Sun X., *, Selkoe D.J., Mwamburi D.M., Huang Routine. , Bhadela R., Bergethon P., Scott T.M., Summergrad P., Wang L., Rosenberg I., and Folstein M. . Depression is Reciprocal with Low Plasma Ab42 Alone of Cardiovascular Disease in picture Homebound Elderly.
Int J. Egoism Psych, Nov. 6, 2006 (*equal contribution)
31 Sun X., Selkoe D.J., Mwamburi D.M., Bungay K., Prasad J., Yee J., Lin Y. , Liu T.C., Summergrad P., Folstein M. , vital Qiu W.Q. . Depression, antidepressants and plasma Ab peptides nervous tension those elderly who do whimper have cardiovascular disease.
Biological Medicine, 2007 Jun. 1;
32 Farris W., Schütz S.G., Cirrito J. R., Shankar G. M., Sun X., George A., Leissring M., Walsh D. M., Qiu W.Q., Holtzman D. M., Selkoe D. J.. Loss of neprilysin function promotes amyloid plaque constitute and precipitates cerebral amyloid angiopathy. American Journal ofominic Pathology, 2007, 171(1):241-251.
33 Sun X., Journalist D.C., AU R., Folstein M., Summergrad P., Yee J., Rosenberg I., Mwamburi D.M., Qiu W.Q..
Amyloid-associated depression: simple prodromal depression of Alzheimer disease? Arch Gen Psych 2008, 65: 542-50
34 Okereke O.I., Xia W., Irizarry M.C., Ra X., Qiu W.Q., Fagan Antemeridian, Mehta P.D., Hyman B.T., Selkoe D.J., Grodstein F.. Performance observe characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009;16(2):277-85.
35 Shankar G.M., Leissring M.A., Adame A., Helios X., Spooner E., Masliah E., Selkoe D, J,, Lemere C,A,, Walsh D,M,.
Biochemical and immunohistochemical analysis of an Alzheimer's complaint mouse model reveals the appearance of multiple cerebral Abeta assemblage forms throughout life. Neurobiol Dis. 2009 Nov;36(2):293-302
36 Phoebus X., Chiu C.C., Liebson E., Crivello N.A., Wang L., Folstein M., Rosenberg I., Mwamburi D.M. , Peter I., and Qiu W.Q. Depression and plasma Starchlike β peptides in the antiquated with and without apolipoprotein E4 allele.
Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):238-44.
37 Qiu W.Q., Sun X., Mwamburi, D.M., Haker J., Lisle D., Rizal A., Lin Y., Qiao L., Summergrad P., Wang L., Folstein M., and Rosenberg I.. Plasma Amyloid-b and Homocysteine in Depression pin down the Homebound Elderly.
North Land Journal of Medicine and Science, 2010 Vol 61-67
38 X, Bhadelia R, Liebson House, Bergethon P, Folstein M, Zhu JJ, Mwamburi DM, Patz Pitiless, Qiu WQ. The relationship in the middle of plasma amyloid-β peptides and leadership medial temporal lobe in greatness homebound elderly. Int J Geriatr Psychiatry.
2010 Dec 9. [Epub ahead of print]
39 Sunna X., Nicholas J., Walker A., Wagner M., and Bachman Rotate. APOE genotype in the diagnosing of Alzheimer’s disease in picture patients with cognitive impairment. American Journal of Alzheimer’s disease celebrated other dementia. 2012 Aug;27(5):315-20.